1980-81 DePaul (27-2) Independents

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22 Nov W vs Louisville 86- 80
(1-0)
1 Dec W Gonzaga 74- 56
(2-0)
6 Dec W Santa Clara 88- 71
(3-0)
8 Dec W Northern Illinois 93- 56
(4-0)
13 Dec W at Texas 83- 65
(5-0)
16 Dec W at North Texas 92- 86
(6-0)
19 Dec W vs Loyola-IL 71- 67
(7-0)
20 Dec W vs Northwestern 62- 54
(8-0)
27 Dec W UCLA 93- 77
(9-0)
29 Dec W vs Georgetown 72- 67
(10-0)
30 Dec W at San Diego St 85- 69
(11-0)
3 Jan W Furman 78- 65
(12-0)
6 Jan W at Maine 85- 77
(13-0)
10 Jan L Old Dominion 62- 63
(13-1)
13 Jan W St Louis 93- 67
(14-1)
18 Jan W Wagner 90- 75
(15-1)
24 Jan W at La Salle 69- 62
(16-1)
28 Jan W at Illinois St 54- 50
(17-1)
1 Feb W Syracuse 91- 69
(18-1)
4 Feb W Detroit Mercy 69- 58
(19-1)
7 Feb W UAB 77- 66
(20-1)
9 Feb W Creighton 83- 57
(21-1)
14 Feb W at Evansville 61- 53
(22-1)
21 Feb W Marquette 78- 71
(23-1)
23 Feb W at Butler 89- 64
(24-1)
28 Feb W Loyola-IL 105- 95
(25-1)
4 Mar W at Dayton 84- 64
(26-1)
8 Mar W Notre Dame 74- 64
(27-1)
14 Mar L vs St Josephs 48- 49
(27-2)