1910 Washington & Jefferson (3-3-1) Independent

Wk 3 Sat 1 Oct L Bethany-WV 0- 3   (0-1)
Wk 4 Sat 8 Oct T at Geneva 0- 0 (0-1-1)
Wk 5 Sat 15 Oct L at Navy 0- 15   (0-2-1)
Wk 7 Sat 29 Oct W at Carnegie Tech 8- 0   (1-2-1)
Wk 8 Sat 5 Nov W Waynesburg 41- 0   (2-2-1)
Wk 9 Sat 12 Nov L at Pittsburgh 0- 14   (2-3-1)
Wk 10 Sat 19 Nov W Villanova 9- 0   (3-3-1)