1999-00 DePaul (21-12) Conference USA

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20 Nov W Howard 105- 61
(1-0)
25 Nov W at AU-Puerto Rico 114- 69
(2-0)
26 Nov L at Texas 64- 68
(2-1)
27 Nov W South Carolina 58- 46
(3-1)
1 Dec W Chicago St 104- 57
(4-1)
4 Dec L at Duke 83- 84
(4-2)
6 Dec W Monmouth 69- 62
(5-2)
9 Dec W Nicholls St 67- 43
(6-2)
14 Dec W St Johns 71- 65
(7-2)
18 Dec L at UCLA 58- 76
(7-3)
23 Dec W Northern Illinois 82- 61
(8-3)
28 Dec W at Memphis 71- 65
(9-3)
30 Dec W Elon 80- 56
(10-3)
8 Jan W Charlotte 77- 75
(11-3)
12 Jan L Marquette 60- 69
(11-4)
16 Jan W at Houston 77- 68
(12-4)
20 Jan L at Louisville 59- 72
(12-5)
22 Jan L St Louis 69- 75
(12-6)
26 Jan W Florida 71- 69
(13-6)
29 Jan L at UAB 68- 69
(13-7)
2 Feb W Tulane 85- 54
(14-7)
6 Feb W at Charlotte 80- 66
(15-7)
8 Feb W South Florida 81- 69
(16-7)
13 Feb L at Cincinnati 64- 87
(16-8)
16 Feb W at Marquette 55- 35
(17-8)
19 Feb L Louisville 54- 71
(17-9)
26 Feb W at St Louis 55- 54
(18-9)
2 Mar L Cincinnati 62- 64
(18-10)
4 Mar W Southern Miss 82- 51
(19-10)
9 Mar W vs Memphis 80- 76
(20-10)
10 Mar W vs Charlotte 56- 49
(21-10)
11 Mar L vs St Louis 49- 56
(21-11)
17 Mar L vs Kansas 77- 81 (O)
(21-12)